Chimpanzees are the closest living relatives of humans. The divergence between human
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …

Human behavior is shaped by social learning to an extent that is unrivaled in the natural
world. What neurobiological changes have occurred in human evolutionary history that have …

Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …

While human cognitive abilities are clearly unique, underlying changes in brain organization
and function remain unresolved. Here we characterized the transcriptome of the cortical …

Brain organoids are proving to be physiologically relevant models for studying human brain
development in terms of temporal transcriptional signature recapitulation, dynamic …

How do epigenetic modifications change across species and how do these modifications
affect evolution? These are fundamental questions at the forefront of our evolutionary …

In this review, we approach Parkinson's disease (PD) in the context of an evolutionary
mismatch of central nervous system functions. The neurons at risk have hyperbranched …

Primate brains vary dramatically in size and organization, but the genetic and
developmental basis for these differences has been difficult to study due to lack of …

The human cerebral cortex contains many cell types that likely underwent independent
functional changes during evolution. However, cell-type–specific regulatory landscapes in …

Mass spectrometry imaging (MSI) has emerged as a powerful tool for multiomics study in
neurology. MSI combines the multichannel (m/z) measurement capability of mass …