Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Mitochondria are double‐membrane‐bound organelles that are present in all nucleated
eukaryotic cells and are responsible for the production of cellular energy in the form of ATP …

Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …

Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA
mutations increase with age in human colorectal epithelium and are prevalent in colorectal …

Genetic and biochemical defects of mitochondrial function are a major cause of human
disease, but their link to mitochondrial morphology in situ has not been defined. Here, we …

Mitochondrial disease is hugely diverse with respect to associated clinical presentations and
underlying genetic causes, with pathogenic variants in over 300 disease genes currently …

Mitophagy is a quality control mechanism that eliminates damaged mitochondria, yet its
significance in mammalian pathophysiology and aging has remained unclear. Here, we …

Mitochondrial myopathies are progressive muscle conditions caused primarily by the
impairment of oxidative phosphorylation (OXPHOS) in the mitochondria. This causes a …

Heteroplasmic mtDNA mutations typically act in a recessive way and cause mitochondrial
disease only if present above a certain threshold level. We have experimentally investigated …

Neurons and glial cells exchange energy-rich metabolites and it has been suggested,
originally based on in vitro data, that astrocytes provide lactate to glutamatergic synapses …