Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Multidrug resistant bacteria are a global threat for human and animal health. However, they
are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to …

The presence of biofilms in chronic non-healing wounds, has been identified through in vitro
model and in vivo animal data. However, human chronic wound studies are under …

Foot infections are the main disabling complication in patients with diabetes mellitus. These
infections can lead to lower-limb amputation, increasing mortality and decreasing the quality …

Biofilms have conventionally been perceived as dense bacterial masses on surfaces,
following the five-step model of development. Initial biofilm research focused on surface …

Active bacterial metabolism is a prerequisite for optimal activity of many classes of
antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic …

Background: Despite a growing consensus that biofilms contribute to a delay in the healing
of chronic wounds, conflicting evidence pertaining to their identification and management …

In the first comprehensive study of Medicare spending in wound care, based on
retrospective analysis of the 2014 Medicare 5% Limited Data Set for acute and chronic …

In this paper, we review and analyze the commonly available wound healing models
reported in the literature and discuss their advantages and issues, considering their …

Chronic wounds represent a large and growing disease burden. Infection and biofilm
formation are two of the leading impediments of wound healing, suggesting an important …