Rare cancers (RCs), which account for over 20% of cancer cases, face significant research
and treatment challenges due to their limited prevalence. This results in suboptimal …

The development of effective and personalized treatment options for patients with rare
cancers like chordoma is hampered by numerous challenges. Biomarker-guided …

Abstract Thiophanate-methyl (TM), a typical pesticide widely used worldwide, was detected
in rivers, soil, fruits, and vegetables. Thus, it is urgent to identify the potential harm of TM …

Background: Skull base chordoma is a rare tumor with low-grade malignancy and a high
recurrence rate, the factors affecting the prognosis of patients need to be further studied. For …

Simple Summary Chordomas are rare malignant bone tumors that predominantly occur
along the spine. The most frequent alterations include the loss of PTEN and p16 proteins …

Background Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease
with poor survival. Although epidermal growth factor receptor (EGFR)‐targeting antibody …

Purpose Chordoma, a rare malignancy of the axial skeleton and skull base, presents
significant therapeutic challenges due to the high rates of tumor recurrence and resistance …

Animal models have been commonly used in immunotherapy research to study the cell
response to external agents and to assess the effectiveness and safety of new therapies …

Objectives As few large studies identify correlative biomarkers in chordoma, our objective
was to use our large, single-center chordoma tumor bank to identify novel signaling …

Chordomas are rare primary malignant tumours of notochordal origin usually arising along
the axial skeleton with particular predilection of the skull base and sacrococcygeal region …