[HTML][HTML] The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis

AJ Luna, JM Young, RT Sterk, V Bondu, FA Schultz… - Antiviral Research, 2023 - Elsevier
Human papillomaviruses (HPVs) are a significant public health concern due to their
widespread transmission, morbidity, and oncogenic potential. Despite efficacious vaccines …

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening

HM Atkins, AA Uslu, JJ Li, DA Shearer, SA Brendle… - Mbio, 2024 - journals.asm.org
ABSTRACT A substantial percentage of the population remains at risk for cervical cancer
due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines …

Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease

LC Gunder, HR Johnson, E Yao, TH Moyer, HA Green… - Viruses, 2023 - mdpi.com
Anal cancer is a major health problem. This study seeks to determine if the topical protease
inhibitor Saquinavir (SQV), is effective at the prevention of anal cancer in transgenic mice …

The use of a topical protease inhibitor, Saquinavir, to alleviate mouse papillomavirus-mediated anal disease

LC Gunder, HR Johnson, HA Green, A Bilger… - Virology, 2022 - Elsevier
Select protease inhibitors (PI) have been found to be effective in decreasing human
papillomavirus oncoprotein expression. This study evaluated whether the topical PI …

Inhibition of cellular MEK/ERK signaling suppresses murine papillomavirus type 1 replicative activities and promotes tumor regression

AJ Luna, JM Young, RT Sterk, V Bondu, FA Schultz… - bioRxiv, 2023 - biorxiv.org
Human papillomaviruses (HPVs) are a significant public health concern due to their
widespread transmission, morbidity, and oncogenic potential. Despite efficacious vaccines …

Drivers of and the Current Church Stand on Infidelity among the Clergy in the Church of the Province of Uganda

R Mulindwa - 2024 - search.proquest.com
Abstract The Church of the Province of Uganda is one of the most well-positioned churches
as far as inculcating good morals, leading people to salvation, and ensuring optimal …