Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Fibrous scaffolds for building hearts and heart parts
Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that
promote and regulate tissue growth, function, and repair. From a structural perspective, the …
promote and regulate tissue growth, function, and repair. From a structural perspective, the …
Three-dimensional transistor arrays for intra-and inter-cellular recording
Electrical impulse generation and its conduction within cells or cellular networks are the
cornerstone of electrophysiology. However, the advancement of the field is limited by …
cornerstone of electrophysiology. However, the advancement of the field is limited by …
Cooperative coupling of cell-matrix and cell–cell adhesions in cardiac muscle
ML McCain, H Lee, Y Aratyn-Schaus… - Proceedings of the …, 2012 - National Acad Sciences
Adhesion between cardiac myocytes is essential for the heart to function as an
electromechanical syncytium. Although cell-matrix and cell–cell adhesions reorganize …
electromechanical syncytium. Although cell-matrix and cell–cell adhesions reorganize …
[HTML][HTML] Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-
threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 …
threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 …
Intercalated disk nanoscale structure regulates cardiac conduction
N Moise, HL Struckman, C Dagher… - Journal of General …, 2021 - rupress.org
The intercalated disk (ID) is a specialized subcellular region that provides electrical and
mechanical connections between myocytes in the heart. The ID has a clearly defined …
mechanical connections between myocytes in the heart. The ID has a clearly defined …
GJA1-20k arranges actin to guide Cx43 delivery to cardiac intercalated discs
WA Basheer, S Xiao, I Epifantseva, Y Fu… - Circulation …, 2017 - Am Heart Assoc
Rationale: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid
process critical for intercellular coupling. By a pathway of targeted delivery involving …
process critical for intercellular coupling. By a pathway of targeted delivery involving …
A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient
After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
An injectable conductive three-dimensional elastic network by tangled surgical-suture spring for heart repair
C Song, X Zhang, L Wang, F Wen, K Xu, W Xiong… - ACS …, 2019 - ACS Publications
Designing scaffolds with persistent elasticity and conductivity to mimic microenvironments
becomes a feasible way to repair cardiac tissue. Injectable biomaterials for cardiac tissue …
becomes a feasible way to repair cardiac tissue. Injectable biomaterials for cardiac tissue …
Characterization of gelatin hydrogels cross-linked with microbial transglutaminase as engineered skeletal muscle substrates
Engineered in vitro models of skeletal muscle are essential for efficiently screening drug
safety and efficacy. However, conventional culture substrates poorly replicate physical …
safety and efficacy. However, conventional culture substrates poorly replicate physical …