Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Background Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of
undetermined significance (CCUS) are defined by somatic mutations in genes associated …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown. The age-related acquisition of …

Importance Clonal hematopoiesis of indeterminate potential (CHIP) is associated with
increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …