Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Q Guo, Y Wang, D Xu, J Nossent, NJ Pavlos, J Xu - Bone research, 2018 - nature.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

Effector and regulatory B cells in immune-mediated kidney disease

K Oleinika, C Mauri, AD Salama - Nature Reviews Nephrology, 2019 - nature.com
B cells have a central role in many autoimmune diseases, including in those with renal
involvement, as well as in the immunological response to kidney transplantation. The …

[HTML][HTML] Outcomes of rituximab therapy in refractory lupus: a meta-analysis

F Alshaiki, E Obaid, A Almuallim, R Taha… - European journal of …, 2018 - ncbi.nlm.nih.gov
Objective Conventional treatment of systemic lupus erythematosus (SLE) and lupus
nephritis (LN) is associated with damage accrual, hence increased morbidity rate. Off-label …

Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future?

G Kour, R Choudhary, S Anjum, A Bhagat… - Biochemical …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disorder and the treatment involves the
use of traditional and biological disease modifying anti-rheumatic drugs (DMARDs). Recent …

Pharmacogenomics of monoclonal antibodies for the treatment of rheumatoid arthritis

SH Lim, K Kim, CI Choi - Journal of Personalized Medicine, 2022 - mdpi.com
Precision medicine refers to a highly individualized and personalized approach to patient
care. Pharmacogenomics is the study of how an individual's genomic profile affects their …

Dietary polyphenols for management of rheumatoid arthritis: Pharmacotherapy and novel delivery systems

S Maity, S Wairkar - Phytotherapy Research, 2022 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic, complex, systemic autoimmune disease causing
chronic inflammation, swelling, and pain. It affects pulmonary and ocular physiology …

The potential role of regulatory B cells in idiopathic membranous nephropathy

Z Dong, Z Liu, H Dai, W Liu, Z Feng… - Journal of …, 2020 - Wiley Online Library
Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an
immunosuppressive role. Breg inhibits pathological autoimmune response by secreting …

Эффективность генно-инженерной биологической терапии и особенности гуморального иммунитета у больных системной красной волчанкой

АА Меснянкина, СК Соловьев, ЕА Асеева… - Научно …, 2018 - cyberleninka.ru
Цель исследования изучить влияние различных генно-инженерных биологических
препаратов (ГИБП), включая комбинированное лечение ритуксимабом (РТМ) и …

Development of Bruton's tyrosine kinase inhibitors for rheumatoid arthritis

J Lv, J Wu, F He, Y Qu, Q Zhang… - Current Medicinal …, 2018 - ingentaconnect.com
Rheumatoid Arthritis (RA) is a chronic autoimmune disease and becomes one of the major
causes of disability and work force loss. The presence of abnormal B cell and …

Autoreactive B‐lymphocytes in SLE and RA patients: isolation and characterisation using extractable nuclear and citrullinated antigens bound to immunobeads

R de la Varga‐Martínez… - European Journal of …, 2019 - Wiley Online Library
Systemic lupus erythematosus and rheumatoid arthritis are autoimmune diseases
characterised by B‐cell hyperactivation and production of autoantibodies (AutoAbs) against …