Targeting cannabinoid signaling in the immune system:“High”-ly exciting questions, possibilities, and challenges

A Oláh, Z Szekanecz, T Bíró - Frontiers in Immunology, 2017 - frontiersin.org
It is well known that certain active ingredients of the plants of Cannabis genus, ie, the
“phytocannabinoids”[pCBs; eg,(−)-trans-Δ9-tetrahydrocannabinol (THC),(−)-cannabidiol …

The interplay between the immune and the endocannabinoid systems in cancer

M Braile, S Marcella, G Marone, MR Galdiero… - Cells, 2021 - mdpi.com
The therapeutic potential of Cannabis sativa has been recognized since ancient times.
Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G …

Cannabinoid Receptor 2 (CB2) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes

Y Saroz, DT Kho, M Glass, ES Graham… - ACS pharmacology & …, 2019 - ACS Publications
Cannabinoid receptor 2 (CB2) is a promising therapeutic target for immunological
modulation. There is, however, a deficit of knowledge regarding CB2 signaling and function …

Cannabinoids and the gastrointestinal tract

M Camilleri, T Zheng - Clinical Gastroenterology and Hepatology, 2023 - Elsevier
The synthesis and degradation of endocannabinoids, location of cannabinoid (CB)
receptors, and cannabinoid mechanisms of action on immune/inflammatory, neuromuscular …

Marijuana and cannabinoids in ESRD and earlier stages of CKD

JL Rein, CM Wyatt - American Journal of Kidney Diseases, 2018 - Elsevier
Marijuana is the most commonly used recreational drug in the United States, and legal
recreational and medicinal use has gained public acceptance during the last decade …

The impact of cannabis consumption on mortality, morbidity, and cost in acute pancreatitis patients in the United States: a 10-year analysis of the national inpatient …

CR Simons-Linares, JA Barkin, S Jang, A Bhatt… - Pancreas, 2019 - journals.lww.com
Objectives The aim of this study was to identify the prevalence of cannabis use among all
patients admitted with acute pancreatitis (AP) in the United States and to investigate the …

An approach to biomarker discovery of cannabis use utilizing proteomic, metabolomic, and lipidomic analyses

JD Hinckley, L Saba, K Raymond, K Bartels… - Cannabis and …, 2022 - liebertpub.com
Introduction: Relatively little is known about the molecular pathways influenced by cannabis
use in humans. We used a multi-omics approach to examine protein, metabolomic, and lipid …

[PDF][PDF] In-vitro and in-vivo supportive research on medicinal properties of Cannabis sativa: A comprehensive review

PK Perera, JID Diddeniya - 2022 - ayurvedjournal.com
Cannabis sativa is an herbaceous plant which is mainly used as a remedy for neurological,
digestive and immunological ailments in traditional medicine. Even though Cannabis is the …

Perioperative management of the pediatric patient on medicinal marijuana: what anesthesiologists should know

KM Flannery, G D'Souza, R Agarwal - Anesthesia & Analgesia, 2019 - journals.lww.com
In 2018, 29 states allow the use of medicinal marijuana. In these states, minors, with
parental permission, are granted access. Use has increased in some states, although there …

The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma

T Togano, N Kim, N Kim, GS Park, AK Park… - Biochemical and …, 2019 - Elsevier
Aim AF1q has a precise oncogenic function. The purpose of this study is to investigate
whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL) …