Regulation of VWF (von Willebrand factor) in inflammatory thrombosis

XD Manz, HJ Bogaard, J Aman - Arteriosclerosis, thrombosis, and …, 2022 - Am Heart Assoc
Increasing evidence indicates that inflammation promotes thrombosis via a VWF (von
Willebrand factor)-mediated mechanism. VWF plays an essential role in maintaining the …

Chronic thromboembolic pulmonary hypertension: realising the potential of multimodal management

M Delcroix, M de Perrot, X Jaïs, DP Jenkins… - The Lancet …, 2023 - thelancet.com
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute
pulmonary embolism. Important advances have enabled better understanding …

Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies

D Das, NR Shruthi, A Banerjee, G Jothimani… - Frontiers in …, 2023 - frontiersin.org
Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of
developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension …

Chronic thromboembolic pulmonary disease

NH Kim, AM D'Armini, M Delcroix, X Jaïs… - European …, 2024 - erj.ersjournals.com
Chronic thromboembolic pulmonary hypertension is a complication of pulmonary embolism
and a treatable cause of pulmonary hypertension. The pathology is a unique combination of …

Mechanisms of COVID-19 associated pulmonary thrombosis: a narrative review

CM Niculae, A Hristea, R Moroti - Biomedicines, 2023 - mdpi.com
COVID-19, the infectious disease caused by severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2), is frequently associated with pulmonary thrombotic events, especially in …

Angiogenesis in Chronic Thromboembolic Pulmonary Hypertension: A Janus-Faced Player?

L Willems, K Kurakula, J Verhaegen… - … and Vascular Biology, 2024 - Am Heart Assoc
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary
hypertension characterized by the presence of organized thrombi that obstruct pulmonary …

A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

AR Bhagwani, M Ali, B Piper, M Liu, J Hudson, N Kelly… - Iscience, 2023 - cell.com
Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells
(ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like …

UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury

W Peng, Y Xie, Z Luo, Y Liu, J Xu, C Li, T Qin… - Journal of …, 2023 - Springer
Macrophages polarized to the M2 subtype after spinal cord injury (SCI) are beneficial for
promoting neurological recovery. The crosstalk between endothelial cells (ECs) and …

Irregularities of Coagulation in Hypertension

S Rafaqat, A Khalid, S Riaz, S Rafaqat - Current Hypertension Reports, 2023 - Springer
Abstract Purpose of Review This review article summarizes the role of coagulation in the
pathogenesis of hypertension. It specifically focuses on significant factors and markers …

The effects of epigenetic modifications on bone remodeling in age-related osteoporosis

W Yu, HL Wang, J Zhang, C Yin - Connective Tissue Research, 2023 - Taylor & Francis
Purpose: As the population ages, there is an increased risk of fracture and morbidity
diseases associated with aging, such as age-related osteoporosis and other bone diseases …