Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

M Dalli, O Bekkouch, S Azizi, A Azghar, N Gseyra… - Biomolecules, 2021 - mdpi.com
Medicinal and aromatic plants are mainly characterized by the presence of different
bioactive compounds which exhibit various therapeutic activities. In order to investigate the …

Bioactive compounds from mangosteen (Garcinia mangostana L.) as an antiviral agent via dual inhibitor mechanism against SARSCoV-2: an in silico approach

ANM Ansori, VD Kharisma, AA Parikesit… - Pharmacognosy …, 2022 - phcogj.com
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes
COVID-19 which is responsible for respiratory illness infection in humans. The virus was first …

Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

M Imran, SA Khan, Abida, MK Alshammari, SM Alkhaldi… - Molecules, 2022 - mdpi.com
COVID-19 has had an impact on human quality of life and economics. Scientists have been
identifying remedies for its prevention and treatment from all possible sources, including …

Metabolites profiling and cheminformatics bioprospection of selected medicinal plants against the main protease and RNA-dependent RNA polymerase of SARS-CoV …

AA Lanrewaju, AM Enitan-Folami… - Journal of …, 2024 - Taylor & Francis
Despite the existence of some vaccines, SARS-CoV-2 (S-2) infections persist for various
reasons relating to vaccine reluctance, rapid mutation rate, and an absence of specific …

In silico study of entry inhibitor from Moringa oleifera bioactive compounds against SARS-CoV-2 infection

N Mawaddani, E Sutiyanti, MH Widyananda… - Pharmacognosy …, 2022 - phcogj.com
The aim of this study is to screen the content of bioactive compounds of Moringa oleifera and
to identify its potential as an antiviral against COVID 19 through an entry inhibitor …

Exploring the inhibitory potential of Nigella sativa against dengue virus NS2B/NS3 protease and NS5 polymerase using computational approaches

M Mukhtar, HA Khan - RSC advances, 2023 - pubs.rsc.org
Dengue fever, a highly infectious and rapidly spreading vector borne illness, is classified as
a Neglected Tropical Disease (NTD) by WHO because they generally afflict the world's poor …

A comprehensive update of various attempts by medicinal chemists to combat COVID-19 through natural products

A Rafiq, T Jabeen, S Aslam, M Ahmad, UA Ashfaq… - Molecules, 2023 - mdpi.com
The ongoing COVID-19 pandemic has resulted in a global panic because of its continual
evolution and recurring spikes. This serious malignancy is caused by the severe acute …

Phytochemical profile, nutritional and medicinal value of Nigella sativa

S Hussain, A Rukhsar, M Iqbal, Q ul Ain, J Fiaz… - Biocatalysis and …, 2024 - Elsevier
This review article provides phytochemical profiling, nutritional and medicinal importance of
Nigella sativa (NS). Its seeds are rich in thymol, thymoquinone, thymohydroquinone …

Plant spices as a source of antimicrobial synergic molecules to treat bacterial and viral co-infections

NBA Duarte, JA Takahashi - Molecules, 2022 - mdpi.com
The COVID-19 pandemic exposed the lack of antiviral agents available for human use, while
the complexity of the physiological changes caused by coronavirus (SARS-CoV-2) imposed …