Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

This new book, The Epilepsies, details the most recent advances in epileptic seizures,
epileptic syndromes and their management. It is based on the International League Against …

Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a
multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and …

Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …

Voltage-gated calcium channels are important mediators of several physiological processes,
including neuronal excitability and muscle contraction. At the molecular level, the channels …

CACNA1A loss-of-function mutations classically present as episodic ataxia type 2 (EA2),
with brief episodes of ataxia and nystagmus, or with progressive spinocerebellar ataxia …