GBP5 exacerbates rosacea‐like skin inflammation by skewing macrophage polarization towards M1 phenotype through the NF‐κB signalling pathway

L Zhou, H Zhao, H Zhao, X Meng… - Journal of the …, 2023 - Wiley Online Library
Background Rosacea is a chronic inflammatory skin disease with increased macrophage
infiltration. However, the molecular mechanism remains unclear. Objectives To determine …

[HTML][HTML] Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types

B Tang, R Yan, J Zhu, S Cheng, C Kong… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a recently described mode of cell death caused by the accumulation of
intracellular iron and lipid reactive oxygen species (ROS), which play critical roles in …

Upregulated of ANXA3, SORL1, and neutrophils may be key factors in the progressionof ankylosing spondylitis

J Jiang, X Zhan, H Qu, T Liang, H Li, L Chen… - Frontiers in …, 2022 - frontiersin.org
Introduction The specific pathogenesis of ankylosing spondylitis (AS) remains unclear, and
our study aimed to investigate the possible pathogenesis of AS. Materials and Methods Two …

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer …

C Wu, ZH Huang, ZQ Meng, XT Fan, S Lu, YY Tan… - Chinese Medicine, 2021 - Springer
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the
treatment of various cancers, especially neoplasms of the digestive system. However, the …

Identification and validation of IFI44 as key biomarker in lupus nephritis

L Shen, L Lan, T Zhu, H Chen, H Gu, C Wang… - Frontiers in …, 2021 - frontiersin.org
Lupus nephritis (LN) is a common and severe organ manifestation of systemic lupus
erythematosus (SLE) and is a major cause of SLE related deaths. Early diagnosis is …

Genomic and Transcriptomic Insights into the Evolution and Divergence of MIKC-Type MADS-Box Genes in Carica papaya

Y Dai, Y Wang, L Zeng, R Jia, L He, X Huang… - International Journal of …, 2023 - mdpi.com
MIKC-type MADS-box genes, also known as type II genes, play a crucial role in regulating
the formation of floral organs and reproductive development in plants. However, the genome …

Serum ferritin diagnosis and prediction of hepatitis B virus‐related acute‐on‐chronic liver failure

J Luo, X Liang, J Xin, P Li, J Li, J Jiang… - Journal of Medical …, 2023 - Wiley Online Library
Early diagnosis and prediction of hepatitis B virus‐related acute‐on‐chronic liver failure
(HBV‐ACLF) is important to reduce mortality. This study aimed to assess the diagnostic and …

A comprehensive weighted gene co-expression network analysis uncovers potential targets in diabetic kidney disease

S Pan, Z Li, Y Wang, L Liang, F Liu, Y Qiao… - Journal of …, 2023 - degruyter.com
Abstract Background and Objectives Diabetic kidney disease (DKD) is one of the most
common microvascular complications of diabetes. It has always been difficult to explore …

Multi-transcriptomic analysis and experimental validation implicate a central role of STAT3 in skin barrier dysfunction induced aggravation of rosacea

Y Wang, B Wang, Y Huang, Y Li, S Yan… - Journal of …, 2022 - Taylor & Francis
Objective Rosacea is a chronic inflammatory skin disease with high morbidity. Previous
studies have described the contribution of skin barrier dysfunction (SBD) in the progression …

[HTML][HTML] Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma

S Li, P Xue, X Diao, QY Fan, K Ye, XM Tang… - Journal of Advanced …, 2023 - Elsevier
Background Aberrations in MYC underlie a large proportion of liver hepatocellular
carcinoma (LIHC) cases; however, MYC is difficult to target because of its undruggable …