A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
Biomolecular condensates and cancer
Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …
have been the subject of detailed genetic, biochemical, and structural studies, but only …
Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins
Collagens are the most abundant components of the extracellular matrix and many types of
soft tissues. Elastin is another major component of certain soft tissues, such as arterial walls …
soft tissues. Elastin is another major component of certain soft tissues, such as arterial walls …
Fluorescent proteins and their applications in imaging living cells and tissues
Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …
diverse marine animals are widely used as universal genetically encoded fluorescent labels …
Single-cell transcriptional profiles in human skeletal muscle
Skeletal muscle is a heterogeneous tissue comprised of muscle fiber and mononuclear cell
types that, in addition to movement, influences immunity, metabolism and cognition. We …
types that, in addition to movement, influences immunity, metabolism and cognition. We …
Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections
JD Humphrey, MA Schwartz, G Tellides… - Circulation …, 2015 - Am Heart Assoc
Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …
Tropoelastin and elastin assembly
Elastic fibers are an important component of the extracellular matrix, providing stretch,
resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the …
resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the …
Assembly of fibronectin extracellular matrix
P Singh, C Carraher… - Annual review of cell and …, 2010 - annualreviews.org
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are
induced to self-associate and to interact with other ECM proteins to form fibrillar networks …
induced to self-associate and to interact with other ECM proteins to form fibrillar networks …
Vascular extracellular matrix and arterial mechanics
JE Wagenseil, RP Mecham - Physiological reviews, 2009 - journals.physiology.org
An important factor in the transition from an open to a closed circulatory system was a
change in vessel wall structure and composition that enabled the large arteries to store and …
change in vessel wall structure and composition that enabled the large arteries to store and …
[HTML][HTML] Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective
LD Muiznieks, FW Keeley - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
The extracellular matrix is an integral and dynamic component of all tissues.
Macromolecular compositions and structural architectures of the matrix are tissue-specific …
Macromolecular compositions and structural architectures of the matrix are tissue-specific …