The cognitive impact of light: illuminating ipRGC circuit mechanisms

HL Mahoney, TM Schmidt - Nature Reviews Neuroscience, 2024 - nature.com
Ever-present in our environments, light entrains circadian rhythms over long timescales,
influencing daily activity patterns, health and performance. Increasing evidence indicates …

Mapping the Retina onto the Brain

D Kerschensteiner, MB Feller - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Vision begins in the retina, which extracts salient features from the environment and
encodes them in the spike trains of retinal ganglion cells (RGCs), the output neurons of the …

Light disrupts social memory via a retina‐to‐supraoptic nucleus circuit

YF Huang, PY Liao, JH Yu, SK Chen - EMBO reports, 2023 - embopress.org
The formation of social memory between individuals of the opposite sex is crucial for
expanding mating options or establishing monogamous pair bonding. A specialized …

Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers

E Zangen, S Hadar, C Lawrence, M Obeid… - Nature …, 2024 - nature.com
While light can affect emotional and cognitive processes of the medial prefrontal cortex
(mPFC), no light-encoding was hitherto identified in this region. Here, extracellular …

Defining spatial nonuniformities of all ipRGC types using an improved Opn4cre recombinase mouse line

B Dyer, OY Sue, RL Brown, RA Lang, SP D'Souza - Cell Reports Methods, 2024 - cell.com
Intrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in several
physiological light responses. In this study, we generate an improved Opn4 cre knockin …

The first interneuron of the mouse visual system is tailored to the natural environment through morphology and electrical coupling

M Spinelli, AA Harnecker, CT Block, L Lindenthal… - iScience, 2024 - cell.com
The topographic complexity of the mouse retina has long been underestimated. However,
functional gradients exist, which reflect the non-uniform statistics of the visual environment …

[PDF][PDF] Light-induced synchronization modulation: Enhanced in weak coupling and attenuated in strong coupling among suprachiasmatic nucleus neurons

Y Xu, C Gu, D Qu, H Wang… - PHYSICAL REVIEW E …, 2025 - researchgate.net
Constant light as a prevalent environmental condition exerts significant and intricate effects
on the circadian system of mammals, particularly concerning behavioral rhythms. In previous …

[HTML][HTML] Flp-recombinase mouse line for genetic manipulation of ipRGCs

E Contreras, C Liang, HL Mahoney, JL Javier, ML Luce… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Light has myriad impacts on behavior, health, and physiology. These signals originate in the
retina and are relayed to the brain by more than 40 types of retinal ganglion cells (RGCs) …

[HTML][HTML] Functional subtypes of rodent melanopsin ganglion cells switch roles between night and day illumination

MH Berry, J Leffler, CN Allen, B Sivyer - bioRxiv, 2023 - ncbi.nlm.nih.gov
Intrinsically photosensitive retinal ganglion cells (ipRGCs), contain the photopigment
melanopsin, and influence both image and non-image forming behaviors. Despite being …

[HTML][HTML] A new Opn4cre recombinase mouse line to target intrinsically photosensitive retinal ganglion cells (ipRGCs)

B Dyer, OY Sue, RL Brown, RA Lang, SP D'Souza - bioRxiv, 2024 - ncbi.nlm.nih.gov
Intrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in several
physiological light responses. In this study we generate a new Opn4 cre knock-in allele …