Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

The covalent marking of proteins by methyl group addition to arginine residues can promote
their recognition by binding partners or can modulate their biological activity. A small family …

V (D) J recombination assembles immunoglobulin and T cell receptor genes during
lymphocyte development through a series of carefully orchestrated DNA breakage and …

Arginine methylation is a common posttranslational modification (PTM). This type of PTM
occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling …

Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …