The dentate gyrus has long been a focal point for studies on the molecular, cellular, and
network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE) …

Current therapies for epilepsy are largely symptomatic and do not affect the underlying
mechanisms of disease progression, ie epileptogenesis. Given the large percentage of …

Status epilepticus (SE), a medical emergency that is typically terminated through
antiepileptic drug treatment, leads to hippocampus dysfunction typified by …

Temporal lobe epilepsy is prevalent and can be difficult to treat effectively. Granule cell axon
(mossy fiber) sprouting is a common neuropathological finding in patients with mesial …

Electroconvulsive therapy (ECT) is the most potent biological therapy in depression. Animal
studies suggest that ECT acts via neuroplasticity effects on limbic structures involved in the …

In humans and experimental animals, structural and functional changes in neural circuits
can accompany the development of epilepsy. In the dentate gyrus, seizures enhance adult …

Dentate granule cell axon (mossy fiber) sprouting is a common abnormality in patients with
temporal lobe epilepsy. Mossy fiber sprouting creates an aberrant positive-feedback network …

Many patients develop temporal lobe epilepsy after trauma, but basic mechanisms
underlying the development of chronic seizures after head injury remain poorly understood …

Seizure-induced sprouting of the mossy fiber pathway in the dentate gyrus has been
observed nearly universally in experimental models of limbic epilepsy and in the epileptic …

Epilepsy is a common neurologic disorder that manifests in diverse ways. There are
numerous seizure types and numerous mechanisms by which the brain generates seizures …