Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …

Sortilin is a type-1 receptor expressed in neurons of the central and peripheral nervous
systems. Initially considered a rather peculiar receptor resembling an intracellular sorting …

Sortilin (∼ 95 kDa) is a member of the recently discovered family of Vps10p-domain
receptors,, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It …

Brain-derived neurotrophic factor (BDNF), after activity-dependent secretion from neurons,
modulates critical nervous system functions. Recently, a variant in the human bdnf gene …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

Neurotrophins have been intensively studied and have multiple roles in the brain.
Neurotrophins are first synthetized as proneurotrophins and then cleaved intracellularly and …

Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …

The peptide neurotensin has been studied for more than 30 years. Although it is widely
distributed in the central and peripheral nervous systems, neurotensin has been more …

Binding of target-derived neurotrophins to Trk receptors at nerve terminals is required to
stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance …

The family of mammalian type-I transmembrane receptors containing a Vps10p domain
contains five members, Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common …