Axons and Schwann cells exist in a highly interdependent relationship: damage to one cell
type invariably leads to pathophysiological changes in the other. Greater understanding of …

Abstract Neuregulin 1 (NRG1) is a multifunctional and versatile protein: its numerous
isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental …

Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic
treatment with conventional antidepressants through BDNF/TrkB signaling. Ketamine in low …

Peripheral nerve injuries are a commonly encountered clinical problem and often result in
long‐term functional defects. The application of stem cells able to differentiate in Schwann …

Finding a viable cell‐based therapy to address peripheral nerve injury holds promise for
enhancing the currently suboptimal microsurgical approaches to peripheral nerve repair …

Genetically modified Schwann cells (SCs) that overexpress neurotrophic factors (NFs),
especially those that overexpress multiple NFs, hold great potential for promoting nerve …

Schwann cells (SCs) are integral to peripheral nerve biology, contributing to saltatory
conduction along axons, nerve and axon development, and axonal regeneration. SCs also …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of motoneurons, which is preceded by loss of neuromuscular …

Laminins promote early stages of peripheral nerve myelination by assembling basement
membranes (BMs) on Schwann cell surfaces, leading to activation of β1 integrins and other …

Strategies that exploit induced pluripotent stem cells (iPSCs) to derive neurons have relied
on cocktails of cytokines and growth factors to bias cell-signaling events in the course of fate …