The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain
JJ Maran, MM Adesina, CR Green, A Kwakowsky… - Ageing Research …, 2023 - Elsevier
With increasing age, structural changes occur in the eye and brain. Neuronal death,
inflammation, vascular disruption, and microglial activation are among many of the …
inflammation, vascular disruption, and microglial activation are among many of the …
[HTML][HTML] Causal Associations of Glaucoma and Age-Related Macular Degeneration with Cataract: A Bidirectional Two-Sample Mendelian Randomisation Study
JH Seo, Y Lee - Genes, 2024 - mdpi.com
Common age-related eye disorders include glaucoma, cataract, and age-related macular
degeneration (AMD); however, little is known about their relationship with age. This study …
degeneration (AMD); however, little is known about their relationship with age. This study …
Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract
H Choquet, M Duot, VA Herrera, SK Shrestha… - Frontiers in …, 2024 - frontiersin.org
Cataract is the leading cause of blindness among the elderly worldwide. Twin and family
studies support an important role for genetic factors in cataract susceptibility with heritability …
studies support an important role for genetic factors in cataract susceptibility with heritability …