Modulating disease-relevant protein-protein interactions (PPIs) using small-molecule
inhibitors is a quite indispensable diagnostic and therapeutic strategy in averting …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Ferroptosis is a type of lipid peroxidation-dependent cell death that is emerging as a
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …

ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …

Coronaviruses have large positive-strand RNA genomes that are 5′ capped and 3′
polyadenylated. The 5′-terminal two-thirds of the genome contain two open reading frames …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …