Epigenetic modifications play a vital role in the preservation of genome integrity and in the
regulation of gene expression. DNA methylation, one of the key mechanisms of epigenetic …

The field of molecular biology is advancing fast with new powerful technologies, sequencing
methods and analysis software being developed constantly. Commonly used tools originally …

Background Early detection of hepatocellular carcinoma (HCC) is important in order to
improve patient prognosis and survival rate. Methylation sequencing combined with neural …

Background Despite the worldwide progress in cancer diagnostics, more sensitive
diagnostic biomarkers are needed. The methylome has been extensively investigated in the …

An optimized hepatocellular carcinoma (HCC)-targeted methylation next generation
sequencing assay was developed to discover HCC-associated methylation markers directly …

Background Liquid biopsy has emerged as a promising, non-invasive diagnostic approach
in oncology because the analysis of circulating tumor DNA (ctDNA) reflects the precise …

Cardiovascular diseases are the foremost contributor to global mortality, presenting a
complex etiology and an expanding array of risk factors. Coronary artery disease …

The Human Leukocyte Antigen (HLA) locus associates with a variety of complex diseases,
particularly autoimmune and inflammatory conditions. The HLA-DR15 haplotype, for …

INTRODUCTION DNA microarray‐based studies report differentially methylated positions
(DMPs) in blood between late‐onset dementia due to Alzheimer's disease (AD) and …

The increasing interest in studying DNA methylation to understand how traits or diseases
develop requires new and flexible approaches for quantifying DNA methylation in a diversity …