Candida albicans pathogenicity mechanisms

FL Mayer, D Wilson, B Hube - Virulence, 2013 - Taylor & Francis
The polymorphic fungus Candida albicans is a member of the normal human microbiome. In
most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Role of heat‐shock proteins in cellular function and in the biology of fungi

S Tiwari, R Thakur, J Shankar - Biotechnology research …, 2015 - Wiley Online Library
Stress (biotic or abiotic) is an unfavourable condition for an organism including fungus. To
overcome stress, organism expresses heat‐shock proteins (Hsps) or chaperons to perform …

Heat shock proteins in infection

A Bolhassani, E Agi - Clinica Chimica Acta, 2019 - Elsevier
Heat shock proteins (HSPs) are constitutively expressed under physiological conditions in
most organisms but their expression can significantly enhance in response to four types of …

Mechanism of Candida pathogenesis: revisiting the vital drivers

IE Mba, EI Nweze - European Journal of Clinical Microbiology & Infectious …, 2020 - Springer
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …

Candida albicans biofilms: antifungal resistance, immune evasion, and emerging therapeutic strategies

FM Fan, Y Liu, YQ Liu, RX Lv, W Sun, WJ Ding… - International Journal of …, 2022 - Elsevier
Candida albicans is a fungal pathogen that can form biofilms on medical devices and host
tissue, resulting in serious, life-threatening infections. These fungal biofilms are inherently …

Candida survival strategies

M Polke, B Hube, ID Jacobsen - Advances in Applied Microbiology, 2015 - Elsevier
Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …

Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans

J Cui, B Ren, Y Tong, H Dai, L Zhang - Virulence, 2015 - Taylor & Francis
Candida albicans, one of the pathogenic Candida species, causes high mortality rate in
immunocompromised and high-risk surgical patients. In the last decade, only one new class …

Fungal persister cells: The basis for recalcitrant infections?

J Wuyts, P Van Dijck, M Holtappels - PLoS pathogens, 2018 - journals.plos.org
Persister cells are a small subpopulation within fungal biofilms that are highly resistant to
high concentrations of antifungals and therefore most likely contribute to the resistance and …

Candida albicans and cancer: Can this yeast induce cancer development or progression?

A Ramirez-Garcia, A Rementeria… - Critical reviews in …, 2016 - Taylor & Francis
There is currently increasing concern about the relation between microbial infections and
cancer. More and more studies support the view that there is an association, above all, when …