Status and challenges of plant-anticancer compounds in cancer treatment
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …
Natural plant compounds: does caffeine, dipotassium glycyrrhizinate, curcumin, and euphol play roles as antitumoral compounds in glioblastoma cell lines?
Many plant-derived compounds are shown to be promising antitumor therapeutic agents by
enhancing apoptosis-related pathways and cell cycle impairment in tumor cells, including …
enhancing apoptosis-related pathways and cell cycle impairment in tumor cells, including …
The role of ingenane diterpenes in cancer therapy: From bioactive secondary compounds to small molecules
ALV Alves, LS da Silva, CA Faleiros… - Natural Product …, 2022 - journals.sagepub.com
Diterpenes are a class of critical taxonomic markers of the Euphorbiaceae family,
representing small compounds (eg, molecules) with a wide range of biological activities and …
representing small compounds (eg, molecules) with a wide range of biological activities and …
13-oxyingenol dodecanoate derivatives induce mitophagy and ferroptosis through targeting TMBIM6 as potential anti-NSCLC agents
Y Wang, L Gu, J Li, R Wang, Y Zhuang, X Li… - European Journal of …, 2024 - Elsevier
Ingenol diterpenoids continue to attract the attention for their extensive biological activity and
novel structural features. To further explore this type of compound as anti-tumor agent, 13 …
novel structural features. To further explore this type of compound as anti-tumor agent, 13 …
Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective
Cancer is the uncontrolled proliferation of abnormal cells that invade other areas, spread to
other organs, and cause metastases, which is the most common cause of death. A review of …
other organs, and cause metastases, which is the most common cause of death. A review of …
Terpenes: A hope for glioblastoma patients
EM Domínguez-Martín, M Magalhães, T Efferth… - New Insights Into …, 2023 - Elsevier
The purpose of this work is to provide a comprehensive analysis of the mechanism of action
of the terpenes currently studied for glioblastoma (GB) treatment and give an insight into the …
of the terpenes currently studied for glioblastoma (GB) treatment and give an insight into the …
Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents
F Kikuyama, S Suzuki, A Jibiki, Y Yokoyama… - Journal of Natural …, 2023 - Springer
Pancreatic cancer is associated with a poor prognosis; thus, there is an urgent need to
develop new and effective treatments. Ingenol mebutate (IM), which is isolated from the latex …
develop new and effective treatments. Ingenol mebutate (IM), which is isolated from the latex …
Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-Phase Arrest on Glioma Cell Lines
VAO Silva, MN Rosa, A Tansini, O Martinho, A Tanuri… - Molecules, 2019 - mdpi.com
The identification of signaling pathways that are involved in gliomagenesis is crucial for
targeted therapy design. In this study we assessed the biological and therapeutic effect of …
targeted therapy design. In this study we assessed the biological and therapeutic effect of …
Detection of HPV16 in cell lines deriving from cervical and head and neck cancer using a genosensor made with a DNA probe on a layer-by-layer matrix
JC Soares, ME Melendez, AC Soares… - Materials Chemistry …, 2020 - pubs.rsc.org
Detection of human papillomavirus 16 (HPV16) is essential for the diagnosis of cervix and
head and neck cancer, which has prompted the development of biosensors to replace the …
head and neck cancer, which has prompted the development of biosensors to replace the …
[HTML][HTML] Euphorbia granulata Forssk: Evaluation of antioxidant activity, cytotoxicity, and apoptosis induction in breast cancer cells
Euphorbia is one of the six largest genera of flowering plants. The Euphorbia species are
widely distributed throughout the world. So, the aim of this study was to investigate the …
widely distributed throughout the world. So, the aim of this study was to investigate the …