B cells, antibodies, and more

W Hoffman, FG Lakkis, G Chalasani - Clinical Journal of the …, 2016 - journals.lww.com
B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

Transplantation and immunosuppression: a review of novel transplant-related immunosuppressant drugs

H Parlakpinar, M Gunata - Immunopharmacology and …, 2021 - Taylor & Francis
Immunosuppressive drugs used in the transplantation period are generally defined as
induction and maintenance therapy. The use of immunosuppressants, which are particularly …

Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial

GD Banham, SM Flint, N Torpey, PA Lyons… - The Lancet, 2018 - thelancet.com
Background B cells produce alloantibodies and activate alloreactive T cells, negatively
affecting kidney transplant survival. By contrast, regulatory B cells are associated with …

Investigational drugs for the treatment of kidney transplant rejection

LK van Vugt, MR Schagen, A de Weerd… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Kidney transplant rejection remains an important clinical problem despite the
development of effective immunosuppressive therapy. Two major types of rejection are …

B cell immunity in solid organ transplantation

GE Karahan, FHJ Claas, S Heidt - Frontiers in immunology, 2017 - frontiersin.org
The contribution of B cells to alloimmune responses is gradually being understood in more
detail. We now know that B cells can perpetuate alloimmune responses in multiple ways:(i) …

Elevated pretransplantation soluble BAFF is associated with an increased risk of acute antibody-mediated rejection

G Banham, D Prezzi, S Harford, CJ Taylor… - …, 2013 - journals.lww.com
Background B cells play an important role in renal allograft pathology, particularly in acute
and chronic antibody-mediated rejection (AMR). B-cell activating factor belonging to the …

Early cytomegalovirus reactivation in renal recipients is associated with high levels of B cell maturation antigen transcript expression prior to transplantation

R Alfaro, L Rodríguez-Aguilar, S Llorente… - International Journal of …, 2023 - mdpi.com
Cytomegalovirus (CMV) infection is the most frequent infection episode in kidney transplant
(KT) recipients. Reactivation usually occurs in the first three months after transplantation and …

Emerging therapies for antibody-mediated rejection in kidney transplantation

F Abuazzam, C Dubrawka, T Abdulhadi… - Journal of Clinical …, 2023 - mdpi.com
Despite the advances in immunosuppressive medications, antibody-mediated rejection
(AMR) continues to be a major cause of kidney allograft failure and remains a barrier to …

Antibody‐mediated rejection in hand transplantation

A Weissenbacher, T Hautz, B Zelger… - Transplant …, 2014 - Wiley Online Library
Clinical relevance of antibody‐mediated rejection (ABMR) in vascularized composite
allotransplantation (VCA) has not been defined. We herein describe a novel type of donor …

Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice

T Möckel, S Boegel, A Schwarting - Plos one, 2023 - journals.plos.org
Acute kidney injury (AKI) accompanies with high morbidity and mortality. Incomplete renal
recovery can lead to chronic and finally end-stage kidney disease, which results in the …