A focus on Rho/ROCK signaling pathway: An emerging therapeutic target in depression

M Hanifa, M Singh, PK Randhawa, AS Jaggi… - European Journal of …, 2023 - Elsevier
Depression is the most common mental health disorder worldwide; however, the exact
cellular and molecular mechanisms of this major depressive disorder are unclear so far …

The role of Rho/ROCK in epileptic seizure-related neuronal damage

Z Wang, D Ren, P Zheng - Metabolic Brain Disease, 2022 - Springer
Epilepsy is one of the most severe neurological disorders characterized by spontaneous
recurrent seizures. Although more than two-thirds of patients can be cured with anti-epileptic …

Social experience in adolescence shapes prefrontal cortex structure and function in adulthood

DC Li, EA Hinton, J Guo, KA Knight, MK Sequeira… - Molecular …, 2024 - nature.com
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC
development is profoundly influenced by the social environment, disruptions to which may …

Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt …

T Qin, F Fang, M Song, R Li, Z Ma, S Ma - Behavioural brain research, 2017 - Elsevier
There is increasing evidence that major depressive disorder (MDD) is also a progressive
neurodegeneration disorder and neuronal damage is the major pathology of MDD …

Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression

L Xu, J Su, L Guo, S Wang, X Deng, S Ma - Neuropharmacology, 2019 - Elsevier
Lysophosphatidic acid (LPA) is a bioactive lipid mediator of inflammation that binds to its
specific cell surface G protein coupled receptors (LPA1-6). It is reported that LPA induced …

The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus

G García-Rojo, C Fresno, N Vilches… - International Journal …, 2017 - academic.oup.com
Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a
limbic structure implicated in mood disorders, are assumed to contribute to symptoms of …

Neurobehavioral impairments predict specific cerebral damage in rat model of subarachnoid hemorrhage

DG Lynch, KA Shah, K Powell, S Wadolowski… - Translational stroke …, 2024 - Springer
Subarachnoid hemorrhage (SAH) is a severe form of stroke that can cause unpredictable
and diffuse cerebral damage, which is difficult to detect until it becomes irreversible …

Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress …

YE Lin, YC Chen, KH Lu, YJ Huang, S Panyod… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacology relevance Cordyceps militaris (Linn.) Link (CM) is a medicinal
mushroom traditionally used in tonics for treating several neurological disorders, including …

Rho-kinase inhibition has antidepressant-like efficacy and expedites dendritic spine pruning in adolescent mice

LP Shapiro, HW Kietzman, J Guo, DG Rainnie… - Neurobiology of …, 2019 - Elsevier
Adolescence represents a critical period of neurodevelopment, defined by structural and
synaptic pruning within the prefrontal cortex. While characteristic of typical development, this …

Inhibition of Rho kinase by GSK 269962 reverses both corticosterone-induced detrusor overactivity and depression-like behaviour in rats

A Wróbel, A Serefko, E Rechberger… - European Journal of …, 2018 - Elsevier
Literature data give clear evidence that upregulated RhoA/Rho-kinase signalling is one of
the factors that may lead to the development of detrusor overactivity and various disorders of …