The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently
altered pathways in human cancer and has a critical role in driving tumor initiation and …

Background Oxidative stress (OS) is an imbalance between oxidant and antioxidant species
and, together with other numerous pathological mechanisms, leads to the degeneration and …

Background: Although inhibition of SGK1 has been shown to delay cancer progression, the
underlying mechanisms have not yet been elucidated. Methods: We investigated the cellular …

Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a
range of biological processes implicated in the response to growth factors like latelet …

Serum and glucocorticoid-induced protein kinase 1 (SGK1) is a member of the “AGC”
subfamily of protein kinases, which shares structural and functional similarities with the AKT …

Major depressive disorder (MDD) is a heterogeneous psychiatric disease characterized by
persistent low mood, diminished interests, and impaired cognitive and social functions. The …

Background Despite SGK1 has been identified and characterized as a tumor-promoting
gene, the functions and underlying mechanisms of SGK1 involved in metastasis regulation …

Tumor cells can undergo diverse responses to cancer therapy. While apoptosis represents
the most desirable outcome, tumor cells can alternatively undergo autophagy and …

Simple Summary In just less than 30 years since the cloning of RANBP1 (RAN binding
protein 1), this review represents the first attempt for a comprehensive and analytical …

Serum-and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of
serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was …