New developments in the management of cytomegalovirus infection after transplantation

A Meesing, RR Razonable - Drugs, 2018 - Springer
Cytomegalovirus (CMV) continues to be one of the most important pathogens that
universally affect solid organ and allogeneic hematopoietic stem cell transplant recipients …

[HTML][HTML] Infectious complications after liver transplantation

MDP Hernandez, P Martin, J Simkins - Gastroenterology & …, 2015 - ncbi.nlm.nih.gov
Orthotopic liver transplantation (OLT) is the standard of care for patients with
decompensated cirrhosis and for patients with hepatocellular carcinoma. More than 6000 …

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene

YT Lin, S Chiweshe, D McCormick, A Raper… - PLoS …, 2020 - journals.plos.org
The genomes of RNA and small DNA viruses of vertebrates display significant suppression
of CpG dinucleotide frequencies. Artificially increasing dinucleotide frequencies results in …

[HTML][HTML] Cytomegalovirus hepatitis in immunocompetent and immunocompromised hosts

T Da Cunha, GY Wu - Journal of Clinical and Translational …, 2021 - ncbi.nlm.nih.gov
Human cytomegalovirus (HCMV) infection is common and affects between 40–100% of the
worldwide population. However, the majority of cases are asymptomatic and when severe …

Evolving challenges with long‐term care of liver transplant recipients

MA Odenwald, HF Roth, A Reticker… - Clinical …, 2023 - Wiley Online Library
The number of liver transplants (LT) performed worldwide continues to rise, and LT
recipients are living longer post‐transplant. This has led to an increasing number of LT …

Clinical correlation of cytomegalovirus infection with CMV-specific CD8+ T-cell immune competence score and lymphocyte subsets in solid organ transplant recipients

A Meesing, RS Abraham, RR Razonable - Transplantation, 2019 - journals.lww.com
Background. Control of cytomegalovirus (CMV) infection after solid organ transplantation
(SOT) requires a functional immune system. We assessed the association between …

The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication

YT Lin, J Prendergast, F Grey - PLoS pathogens, 2017 - journals.plos.org
The human cytomegalovirus major immediate early proteins IE1 and IE2 are critical drivers
of virus replication and are considered pivotal in determining the balance between …

Cytomegalovirus infection in liver transplant recipients: current approach to diagnosis and management

SK Yadav, S Saigal, NS Choudhary, S Saha… - Journal of clinical and …, 2017 - Elsevier
Cytomegalovirus (CMV) infection is the most common viral infection in liver transplant
recipients, affecting post-transplant patients and graft survival. Recent advances in …

Coinfection rates and clinical outcome data for cytomegalovirus and Epstein‐Barr virus in post‐transplant patients: A systematic review of the literature

C Anderson‐Smits, ER Baker… - Transplant Infectious …, 2020 - Wiley Online Library
Background In transplant recipients, cytomegalovirus (CMV) infection increases morbidity
and mortality; furthermore, coinfection with other human herpesviruses like the Epstein‐Barr …

[HTML][HTML] Universal prophylaxis or preemptive strategy for cytomegalovirus disease after liver transplantation: a systematic review and meta-analysis

K Mumtaz, N Faisal, S Husain, A Morillo… - American Journal of …, 2015 - Elsevier
We systematically reviewed and meta-analyze the efficacy of universal prophylaxis (UP) and
preemptive (PE) strategies (using ganciclovir or valganciclovir) in preventing …