Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

Most of the colorectal cancer (CRC) cases are sporadic, only 25% of the patients have a
family history of the disease, and major genes causing syndromes predisposing to CRC only …

African Americans have the highest incidence and mortality rates of colorectal cancer (CRC)
of any ethnic group in the United States. Although some of these disparities can be …

We have developed an enhanced form of reduced representation bisulfite sequencing with
extended genomic coverage, which resulted in greater capture of DNA methylation …

MicroRNAs (miRNAs), small noncoding RNAs, can control gene expression by binding to
their target genes for degradation and/or translational repression. Epigenetic mechanisms …

Molecularly targeted therapies are rapidly growing with respect to their clinical development
and impact on cancer treatment due to their highly selective anti-tumor action. However …

BACKGROUND DNA methylation patterns differ among children and adults and play an
unambiguous role in several disease processes, particularly cancers. The origin of these …

Probiotics are defined as live bacteria and yeasts that exert beneficial effects for health.
Among their various effects, anti-cancer properties have been highlighted in recent years …

Background LGR6 (leucine-rich repeat containing, G protein-coupled receptor 6) is a
member of the rhodopsin-like seven transmembrane domain receptor superfamily with the …

Several studies have proved that DNA methylation affects regulation of gene expression and
development. Epigenome-wide studies have reported variation in methylation patterns …