Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Cancer is a major public health problem around the world. Currently, about 5% of women
diagnosed with cancer are of reproductive age. These young survivors may face …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Fertility preservation is an emerging discipline, which is of substantial clinical value in the
care of young patients with cancer. Chemotherapy and radiation may induce ovarian …

BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …

The survival rate of cancer patients is steadily increasing, owing to more efficient therapies.
Understanding the molecular mechanisms of chemotherapy-induced premature ovarian …

Primary ovarian insufficiency (POI) is defined as a reduction in ovarian function before the
expected age of menopause. POI is known to increase the risk of cardiovascular disorders …

It is well established that DNA-damaging chemotherapies can cause infertility and ovarian
endocrine failure by depleting the ovarian reserve of primordial follicles. Currently, no …

Cancer therapy can cause off-target effects including ovarian damage, which may result in
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …

Purpose Chemotherapy treatment in premenopausal women has been linked to ovarian
follicle loss and premature ovarian failure; the exact mechanism by which this occurs is …