Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …

Leonurine refers to the desiccated aerial portion of a plant in the Labiatae family. The
primary bioactive constituent of Leonurine is an alkaloid, Leonurine alkaloid (Leo) …

Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …

Irisin, a myokine secreted by muscle during physical exercise, is known to have biological
activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown …

Osteoporosis bears an imbalance between bone formation and resorption, which is strongly
related to oxidative stress. The function of leonurine on bone marrow-derived mesenchymal …

Background Leonurine, a major bioactive component from Herba leonuri, has been shown
to exhibit anti-inflammatory and antioxidant effects. The aim of this study was to investigate …

Background Premature ovarian insufficiency is common in clinically infertile patients. The
NOD-like receptor family pyrin domain-containing 3 (NLRP3)/Gasdermin D (GSDMD) …

Inflammation of chondrocytes plays a critical role in the occurrence and development of
osteoarthritis (OA). Recent evidence indicated exosomes derived from mesenchymal stem …

Purpose. OA is a multifactorial joint disease in which inflammation plays a substantial role in
the destruction of joints. Corynoline (COR), a component of Corydalis bungeana Turcz., has …

Huoxuezhitong capsule (HXZT, activating blood circulation and relieving pain capsule), has
been applied for osteoarthritis since 1974. It consists of Angelica sinensis (Oliv.) Diels …