A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …

A pathway from the natively unfolded microtubule-associated protein Tau to a highly
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …

Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …

The development of α‐synuclein immunoreactive aggregates in selectively vulnerable
neuronal types of the human central, peripheral, and enteric nervous systems is crucial for …

The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's
disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau …

Tau pathology is known to spread in a hierarchical pattern in Alzheimer's disease (AD) brain
during disease progression, likely by trans-synaptic tau transfer between neurons. However …

Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-
like domain-containing protein and component of pathological intracellular aggregates …