Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the
expression and mobility of transposable elements (TEs). Owing to their ability to recruit the …

Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of
cancer accompanied by global chromosomal instability, genomic instability, and genetic …

A random forest (RF) predictor is an ensemble of individual tree predictors. As part of their
construction, RF predictors naturally lead to a dissimilarity measure between the …

There are clear theoretical reasons and many well-documented examples which show that
repetitive DNA is essential for genome function. Generic repeated signals in the DNA are …

Imprinted genes are essential in embryonic development, and imprinting dysregulation
contributes to human disease. We report two new human imprinted genes: KCNK9 is …

Epigenomic studies aim to define the location and nature of the genomic sequences that are
epigenetically modified. Much progress has been made towards whole-genome epigenetic …

The genomes of multicellular eukaryotes provide information that determines the phenotype.
However, not all sequences in the genome are required for this purpose. Other sequences …

Imprinted genes are epigenetically modified genes whose expression is determined
according to their parent of origin. They are involved in embryonic development, and …

The mechanisms that regulate variable (V) gene selection during the development of the
mouse IgH repertoire are not fully understood, due in part to the absence of the complete …

X chromosome inactivation (XCI) and allelic exclusion of olfactory receptors or
immunoglobulin loci represent classic examples of random monoallelic expression (RME) …