The retina is among the highest organized tissues of the central nervous system. To achieve
such organization, a finely tuned regulation of developmental processes is required to form …

Programmed cell death is important for the proper development of the retina, and
microRNAs (miRNAs) may be critical for its regulation. Here, we report that miR-24a is …

Photoreceptor death is the ultimate cause of vision loss in many retinal degenerative
conditions. Identifying novel therapeutic avenues for prolonging photoreceptor health and …

Vertebrate eye development is complex and requires early interactions between
neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog …

We have previously characterized human neuronal progenitor cells (hNP) that can adopt a
retinal ganglion cell (RGC)-like morphology within the RGC and nerve fiber layers of the …

Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases that play an
instrumental role in signal transduction from the cell surface to the nucleus. These enzymes …

Purpose.: Postnatal exposure to hyperoxia destroys the plexiform layers of the neonatal rat
retina, resulting in significant electroretinographic anomalies. The purpose of this study was …

Controversy exists as to whether the muscle-specific E3 ubiquitin ligases MAFbx and
MuRF1 are transcriptionally upregulated in the process of sarcopenia. In the present study …

Precise coordination of progenitor cell proliferation and differentiation is essential for proper
organ morphogenesis and function during mammalian development. The mitogen-activated …

Apaf‐1 and the cysteine proteases known as caspases are genes central to the intrinsic
apoptotic pathway in the retina. Previously, we have shown that histone deacetylase …