Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Recently, a range of prescription and over-the-counter drugs have been reportedly used as
Novel Psychoactive Substances (NPS), due to their potential for abuse resulting from their …

Development of technology platforms to perform compound screens of human induced
pluripotent stem cell (hiPSC)-derived neurons with relatively high throughput is essential to …

Purpose/Background A recent years' increase in both prescribing and availability of second-
generation antipsychotics (SGAs) has been observed. According to the literature, typically …

Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine
antagonist, potent 5-HT2A-blocking, partial 5-HT1A-agonist, anti-H1 histamine, adrenolytic …

An increasing number of antisense oligonucleotides (ASOs) have been approved for clinical
use. However, improvements of both efficacy and safety in the central nervous system (CNS) …

Obesity and eating disorders are widespread in Western societies. Both the increased
availability of highly palatable foods and dieting are major risk factors contributing to the …

Aryl bromides 2a and 2b bearing an alkynyl substituent in the o-position reacted with n-
butyllithium and 1-benzylpiperidin-4-one in a one-pot Domino reaction to form ester 3 and …

N-methyl-D-aspartate receptor (NMDAR) antagonist, a subclass of glutamate receptors or
nitric oxide synthase (NOS) inhibitors, prevents neuronal plasticity. However, neural …

Starting from enantiomerically pure amino acids, 1, 4-diazepanes with various substituents
in 1, 2, and 4-position were synthesized following the late stage diversification strategy. The …