Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …

Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic
syndrome. Although deposition of excess triglycerides within liver cells, a hallmark of …

We present a method of producing bulk cell-cultured fat tissue for food applications. Mass
transport limitations (nutrients, oxygen, waste diffusion) of macroscale 3D tissue culture are …

In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning
and performs metabolic regulatory functions. It is the most flexible tissue in the body …

Obesity and lipoatrophy are major risks for insulin resistance, non-insulin-dependent
diabetes and cardiovascular disease. In the past three decades, significant advances have …

Combination antiretroviral therapy (cART) against HIV infection dramatically reduces AIDS-
related morbidity. However, many patients under cART display HIV-associated …

Background The optimum dose of key antiretroviral drugs is often overlooked during product
development. The ENCORE1 study compared the efficacy and safety of reduced dose …

The combined pharmacological approach to the treatment of HIV infection, known as highly
active antiretroviral therapy (HAART), has dramatically reduced AIDS-related morbidity and …

Efavirenz (EFV) is a non‐nucleoside reverse transcriptase inhibitor (NNRTI) widely used in
human immunodeficiency virus (HIV) infection therapy. It has been associated with …