Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally
proposed to correct for the blurring effect of atmospheric turbulence on images in ground …

Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

The past quarter century has witnessed rapid developments of fluorescence microscopy
techniques that enable structural and functional imaging of biological specimens at …

Single-molecule super-resolution fluorescence microscopy and single-particle tracking are
two imaging modalities that illuminate the properties of cells and materials on spatial scales …

Far-field optical microscopy using focused light is an important tool in a number of scientific
disciplines including chemical,(bio) physical and biomedical research, particularly with …

Fluorescence nanoscopy, or super-resolution microscopy, has become an important tool in
cell biological research. However, because of its usually inferior resolution in the depth …

Tilted light sheet microscopy with 3D point spread functions (TILT3D) combines a novel,
tilted light sheet illumination strategy with long axial range point spread functions (PSFs) for …

Optical microscopy is widely used to visualize fine structures. When applied to bioimaging,
its performance is often degraded by sample-induced aberrations. In recent years, adaptive …

Specimen-induced aberration has been a major factor limiting the imaging depth of single-
molecule localization microscopy (SMLM). Here, we report the application of label-free …

Combining the molecular specificity of fluorescent probes with three-dimensional imaging at
nanoscale resolution is critical for investigating the spatial organization and interactions of …