Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

Y Furuta, T Komeno, T Nakamura - … of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Abstract Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent
that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA …

Global research trends of World Health Organization's top eight emerging pathogens

WM Sweileh - Globalization and health, 2017 - Springer
Abstract Background On December 8 th, 2015, World Health Organization published a
priority list of eight pathogens expected to cause severe outbreaks in the near future. To …

Mapping global environmental suitability for Zika virus

JP Messina, MUG Kraemer, OJ Brady, DM Pigott… - elife, 2016 - elifesciences.org
Zika virus was discovered in Uganda in 1947 and is transmitted by Aedes mosquitoes,
which also act as vectors for dengue and chikungunya viruses throughout much of the …

Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades

R Klitting, LE Kafetzopoulou, W Thiery, G Dudas… - Nature …, 2022 - nature.com
Lassa fever is a severe viral hemorrhagic fever caused by a zoonotic virus that repeatedly
spills over to humans from its rodent reservoirs. It is currently not known how climate and …

Comparison of social resistance to Ebola response in Sierra Leone and Guinea suggests explanations lie in political configurations not culture

A Wilkinson, J Fairhead - Critical public health, 2017 - Taylor & Francis
Abstract Sierra Leone and Guinea share broadly similar cultural worlds, straddling the
societies of the Upper Guinea Coast with Islamic West Africa. There was, however, a notable …

Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever

T Abreu-Mota, KR Hagen, K Cooper… - Nature …, 2018 - nature.com
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no
approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and …

Lassa fever: epidemiology, clinical features, diagnosis, management and prevention

DA Asogun, S Günther, GO Akpede… - Infectious Disease …, 2019 - id.theclinics.com
Lassa fever, is an acute zoonotic disease of humans that is mainly endemic to West African
countries of Guinea, Liberia, Nigeria, and Sierra Leone. 1–3 Other countries such as Mali …

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

EJ Mateer, C Huang, NY Shehu… - PLoS neglected tropical …, 2018 - journals.plos.org
Although an association between Lassa fever (LF) and sudden-onset sensorineural hearing
loss (SNHL) was confirmed clinically in 1990, the prevalence of LF-induced SNHL in …

Climate change and the neglected tropical diseases

M Booth - Advances in parasitology, 2018 - Elsevier
Climate change is expected to impact across every domain of society, including health. The
majority of the world's population is susceptible to pathological, infectious disease whose life …

Health and economic impacts of Lassa vaccination campaigns in West Africa

DRM Smith, J Turner, P Fahr, LA Attfield, PR Bessell… - Nature medicine, 2024 - nature.com
Lassa fever is a zoonotic disease identified by the World Health Organization (WHO) as
having pandemic potential. This study estimates the health-economic burden of Lassa fever …