Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

LP Jordheim, D Durantel, F Zoulim… - Nature reviews Drug …, 2013 - nature.com
Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …

Nanocarriers for antibiotics: a promising solution to treat intracellular bacterial infections

N Abed, P Couvreur - International journal of antimicrobial agents, 2014 - Elsevier
In the field of antibiotherapy, intracellular infections remain difficult to eradicate mainly due to
the poor intracellular penetration of most of the commonly used antibiotics. Bacteria have …

Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application

ZM Avval, L Malekpour, F Raeisi… - Drug metabolism …, 2020 - Taylor & Francis
In this article, the recent applications of different types of magnetic nanoparticles such as α-
Fe2O3 (hematite), γ-Fe2O3 (maghemite), Fe3O4 (magnetite), hexagonal (MFe12O19) …

Prodrug-based intracellular delivery of anticancer agents

L Bildstein, C Dubernet, P Couvreur - Advanced drug delivery reviews, 2011 - Elsevier
There are numerous anticancer agents based on a prodrug approach. However, no attempt
has been made to review the ample available literature with a specific focus on the altered …

Gemcitabine versus modified gemcitabine: a review of several promising chemical modifications

E Moysan, G Bastiat, JP Benoit - Molecular pharmaceutics, 2013 - ACS Publications
Gemcitabine, an anticancer agent which acts against a wide range of solid tumors, is known
to be rapidly deaminated in blood to the inactive metabolite 2′, 2′-difluorodeoxyuridine …

Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution

S Dufort, L Sancey, JL Coll - Advanced drug delivery reviews, 2012 - Elsevier
Nanoparticles are efficient to safely deliver therapeutic and imaging contrast agents to
tumors for cancer diagnostic and therapy, if they can escape the reticuloendothelial system …

Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

D Sobot, S Mura, SO Yesylevskyy, L Dalbin… - Nature …, 2017 - nature.com
Once introduced in the organism, the interaction of nanoparticles with various biomolecules
strongly impacts their fate. Here we show that nanoparticles made of the squalene derivative …

Investigate the relation between Baicalin effect and gene expression of LH, FSH, Testosterone in male rats treated with Gemcitabine drug

MT Qasim, HK Al-Mayali - Research Journal of Pharmacy and …, 2019 - indianjournals.com
Background Baicalin is a flavonoid that is extracted from the Chinese herbal plant, which is a
member of the mint group, which is known as the (Scutellaria baicalensis, golden root …

Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug

M Parsian, G Unsoy, P Mutlu, S Yalcin… - European journal of …, 2016 - Elsevier
Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse
effects. Among various delivery systems, chitosan coated iron oxide nanoparticles …

Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics

JL Arias, LH Reddy, M Othman, B Gillet, D Desmaele… - ACS …, 2011 - ACS Publications
This study reports the design of a novel theragnostic nanomedicine which combines (i) the
ability to target a prodrug of gemcitabine to an experimental solid tumor under the influence …