Nasal route for vaccine and drug delivery: Features and current opportunities
YL Mato - International journal of pharmaceutics, 2019 - Elsevier
Mucosal administration, and specifically nasal route, constitutes an alternative and
promising strategy for drug and vaccine delivery. Mucosal routes have several advantages …
promising strategy for drug and vaccine delivery. Mucosal routes have several advantages …
Modeling the within-host dynamics of HIV infection
AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …
models of human immunodeficiency virus (HIV), but now includes many viral infections …
HIV persists throughout deep tissues with repopulation from multiple anatomical sources
BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells
Initiation of antiretroviral therapy during the earliest stages of HIV-1 infection may limit the
seeding of a long-lasting viral reservoir, but long-term effects of early antiretroviral treatment …
seeding of a long-lasting viral reservoir, but long-term effects of early antiretroviral treatment …
Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation
A Schuetz, C Deleage, I Sereti, R Rerknimitr… - PLoS …, 2014 - journals.plos.org
Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus
prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell …
prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell …
HIV-1 persistence in CD4+ T cells with stem cell–like properties
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely
defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells …
defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells …
HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat
NM Archin, R Bateson, MK Tripathy… - The Journal of …, 2014 - academic.oup.com
Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-
regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human …
regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human …
[HTML][HTML] Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
The latent reservoir for HIV-1: how immunologic memory and clonal expansion contribute to HIV-1 persistence
Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …
below the limit of detection of clinical assays. However, even with prolonged suppression of …