RNA in extracellular vesicles

KM Kim, K Abdelmohsen, M Mustapic… - Wiley …, 2017 - Wiley Online Library
Cells release a range of membrane‐enclosed extracellular vesicles (EVs) into the
environment. Among them, exosomes and microvesicles (collectively measuring 40–1000 …

Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

E Chirshev, KC Oberg, YJ Ioffe… - Clinical and translational …, 2019 - Springer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …

Integrated extracellular microRNA profiling for ovarian cancer screening

A Yokoi, J Matsuzaki, Y Yamamoto, Y Yoneoka… - Nature …, 2018 - nature.com
A major obstacle to improving prognoses in ovarian cancer is the lack of effective screening
methods for early detection. Circulating microRNAs (miRNAs) have been recognized as …

Isolation and analysis methods of extracellular vesicles (EVs)

Z Zhao, H Wijerathne, AK Godwin… - … vesicles and circulating …, 2020 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) have been recognized as an evolving biomarker within the
liquid biopsy family. While carrying both host cell proteins and different types of RNAs, EVs …

New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Clinical relevance of circulating cell-free microRNAs in ovarian cancer

K Nakamura, K Sawada, A Yoshimura, Y Kinose… - Molecular cancer, 2016 - Springer
Ovarian cancer is the leading cause of death among gynecologic malignancies. Since
ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and …

Liquid biopsy in ovarian cancer: the potential of circulating miRNAs and exosomes

L Giannopoulou, M Zavridou, S Kasimir-Bauer… - Translational …, 2019 - Elsevier
Ovarian cancer still remains the most lethal female cancer, since in most cases it is
diagnosed at an advanced stage. Usually after completion of primary treatment …

Circulating cell-free microRNAs as clinical cancer biomarkers

V Armand-Labit, A Pradines - Biomolecular concepts, 2017 - degruyter.com
MicroRNAs (miRNAs) are non-coding small RNAs that are master regulators of genic
expression and consequently of many cellular processes. But their expression is often …

Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

KM Elias, W Fendler, K Stawiski, SJ Fiascone… - Elife, 2017 - elifesciences.org
Recent studies posit a role for non-coding RNAs in epithelial ovarian cancer (EOC).
Combining small RNA sequencing from 179 human serum samples with a neural network …

MicroRNA biogenesis, gene silencing mechanisms and role in breast, ovarian and prostate cancer

S Khan, H Ayub, T Khan, F Wahid - Biochimie, 2019 - Elsevier
Micro-ribonucleic acids (miRNAs) are important class of short regulatory RNA molecules
involved in regulation of several essential biological processes. In addition to Dicer and …