Caffeine causes most of its biological effects via antagonizing all types of adenosine
receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Highlights•Adenosine contributes to tissue integrity by modulating the immune
system.•Adenosine receptor ligands emerged for the management of inflammation.•These …

Increasing evidence suggests that regular consumption of coffee, tea and dark chocolate
(cacao) can promote brain health and may reduce the risk of age-related neurodegenerative …

Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …

Huntington's disease (HD) is caused by a CAG repeat expansion in exon 1 of the HD gene
resulting in a long polyglutamine tract in the N‐terminus of the protein huntingtin. Patients …

Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …

The interest on targeting adenosine A2A receptors in the realm of psychiatric diseases first
arose based on their tight physical and functional interaction with dopamine D2 receptors …

Huntington's disease is an autosomal dominant disorder caused by a mutation in the gene
encoding the protein huntingtin on chromosome 4. The mutation is an expanded CAG …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …