Building a better understanding of the intracellular tyrosine kinase PTK6—BRK by BRK
Protein tyrosine kinase 6 (PTK6), also referred to as breast tumor kinase BRK, is a member
of a distinct family of kinases that is evolutionarily related to the SRC family of tyrosine …
of a distinct family of kinases that is evolutionarily related to the SRC family of tyrosine …
Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy
The development of cancer is not just the growth and proliferation of a single transformed
cell, but its surrounding environment also coevolves with it. Indeed, successful cancer …
cell, but its surrounding environment also coevolves with it. Indeed, successful cancer …
Electrochemical aptasensor for human osteopontin detection using a DNA aptamer selected by SELEX
A DNA aptamer with affinity and specificity for human osteopontin (OPN), a potential breast
cancer biomarker, was selected using the SELEX process, considering its homology rate …
cancer biomarker, was selected using the SELEX process, considering its homology rate …
[HTML][HTML] Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells
XL Wu, KJ Lin, AP Bai, WX Wang… - World journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To investigate the effects of osteopontin (OPN) gene expression knockdown on colon
cancer Lovo cells in vitro. METHODS: Four candidate small interfering RNA (siRNA) …
cancer Lovo cells in vitro. METHODS: Four candidate small interfering RNA (siRNA) …
Development of an electrochemical RNA-aptasensor to detect human osteopontin
Electrochemical aptasensors may be used to detect protein biomarkers related to tumor
activity. Osteopontin (OPN), a protein present in several body fluids, has been suggested as …
activity. Osteopontin (OPN), a protein present in several body fluids, has been suggested as …
Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer
Y Jin, D Tong, J Chen, Z Feng, J Yang, C Shao, J Li - PloS one, 2012 - journals.plos.org
In this study, we examined the expression of osteopontin (OPN), αvβ3 and Pim-1 in non-
small cell lung cancer (NSCLC) and investigated the potential clinical implications of their …
small cell lung cancer (NSCLC) and investigated the potential clinical implications of their …
[HTML][HTML] Osteopontin b and c splice isoforms in leukemias and solid tumors: angiogenesis alongside chemoresistance
A Mirzaei, S Mohammadi, SH Ghaffari… - Asian Pacific Journal …, 2018 - ncbi.nlm.nih.gov
Osteopontin (OPN) is a glycoprotein involved in regulation of various influences on tumor
progression, such as cellular proliferation, apoptosis, angiogenesis, and metastasis …
progression, such as cellular proliferation, apoptosis, angiogenesis, and metastasis …
A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells
H Liu, A Chen, F Guo, L Yuan - Cancer letters, 2010 - Elsevier
Osteopontin (OPN), a secreted phosphoglycoprotein, is frequently associated with cell
proliferation and tumor metastatic spread in a variety of cancers. It has been reported that …
proliferation and tumor metastatic spread in a variety of cancers. It has been reported that …
Proteins involved in regulating bone invasion in skull base meningiomas
Background Bone invasive skull base meningiomas are a subset of meningiomas that
present a unique clinical challenge due to brain and neural structure involvement and …
present a unique clinical challenge due to brain and neural structure involvement and …
Osteopontin as a key mediator for vasculogenic mimicry in hepatocellular carcinoma
W Liu, G Xu, J Ma, W Jia, J Li, K Chen… - The Tohoku Journal of …, 2011 - jstage.jst.go.jp
Osteopontin (OPN) is overexpressed in a variety of cancers including hepatocellular
carcinoma (HCC), and is likely involved in the process of vasculogenic mimicry (VM) in …
carcinoma (HCC), and is likely involved in the process of vasculogenic mimicry (VM) in …