Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …

ABSTRACT Tissue Inhibitor of Metalloproteinase‐2 (TIMP‐2) is part of the tissue inhibitors of
the metalloproteinases (TIMPs) family. Its primary function is to regulate the activity of matrix …

Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix
metalloproteinase-2 and is highly expressed in breast cancer (BC) cases at diagnosis …

The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and
CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer …

Paclitaxel (PTX) is commonly used in clinical tumor therapy. However, chemoresistance and
the inducement of tumor metastasis severely affect the efficacy of PTX. To develop a …

Tumor cells are highly motile and invasive and display altered gene expression patterns.
Knowledge of how changes in gene expression regulate tumor cell migration and invasion …

Ovarian Cancer (OC) is the leading cause of gynecologic cancer-related deaths worldwide.
The leading risk factors for OC-related death are OC recurrence and the development of …