The entropy-controlled strategy in self-assembling systems

X Zhang, X Dai, L Gao, D Xu, H Wan, Y Wang… - Chemical Society …, 2023 - pubs.rsc.org
Self-assembly of various building blocks has been considered as a powerful approach to
generate novel materials with tailorable structures and optimal properties. Understanding …

Self-assembly and biophysical properties of archaeal lipids

A Bhattacharya - Emerging Topics in Life Sciences, 2022 - portlandpress.com
Archaea constitute one of the three fundamental domains of life. Archaea possess unique
lipids in their cell membranes which distinguish them from bacteria and eukaryotes. This …

Configurational entropy-enabled thermostability of cell membranes in extremophiles: from molecular mechanism to bioinspired design

Z Xu, G Liu, L Gao, D Xu, H Wan, X Dai, X Zhang… - Nano Letters, 2023 - ACS Publications
Understanding physicochemical interactions and mechanisms related to the cell
membranes of lives under extreme conditions is of essential importance but remains …

Structure–function relationships in pure archaeal bipolar tetraether lipids

A Bhattacharya, ID Falk, FR Moss, TM Weiss… - Chemical …, 2024 - pubs.rsc.org
Archaeal bipolar tetraether lipids (BTLs) are among the most unusual lipids occurring in
nature because of their presumed ability to span the entire membrane to form a monolayer …

Antivesiculation and Complete Unbinding of Tail-Tethered Lipids

KC Shih, G Leriche, CH Liu, J He, VT John, J Fang… - Langmuir, 2024 - ACS Publications
We report the effect of tail-tethering on vesiculation and complete unbinding of bilayered
membranes. Amphiphilic molecules of a bolalipid, resembling the tail-tethered molecular …

Entropy‐Mediated Nanoparticle Cellular Uptake

H Wan, D Xu, L Gao, LT Yan - Small Science, 2024 - Wiley Online Library
Entropy, as one of the key parameters defining thermodynamic systems, is extensively
explored in various scientific fields covering physics, chemistry, biology, etc. Particularly …

A single-liposome assay that enables temperature-dependent measurement of proton permeability of extremophile-inspired lipid membranes

A Guha, ML McGuire, G Leriche, J Yang… - Biochimica et Biophysica …, 2021 - Elsevier
Thermoacidophilic archaea are able to survive in low pH environments by maintaining large
proton gradients across their cell membranes. The unique structure of the unipolar and …

Stability vs flexibility: reshaping monolayer and bilayer archaeal membranes in silico

M Amaral, F Frey, X Jiang, B Baum, A Šarić - bioRxiv, 2024 - biorxiv.org
Across the tree of life, distinct designs of cellular membranes have evolved that are both
stable and flexible. In bacteria and eukaryotes this trade-off is accomplished by single …

Fusion of bipolar tetraether lipid membranes without enhanced leakage of small molecules

G Leriche, D Stengel, D Onofrei, T Koyanagi… - Scientific Reports, 2019 - nature.com
A major challenge in liposomal research is to minimize the leakage of encapsulated cargo
from either uncontrolled passive permeability across the liposomal membrane or upon …

Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT-0

ID Falk, B Gál, A Bhattacharya, JH Wei, PV Welander… - 2021 - chemrxiv.org
Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual
membrane lipids identified in nature. These amphiphiles are the major constituents of the …