The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

Mammalian homologues of the Drosophila transient receptor potential (TRP) channel gene
encode a family of at least 20 ion channel proteins. They are widely distributed in …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

▪ Abstract Ion channels are pore-forming transmembrane proteins that allow ions to
permeate biological membranes. Pore structure plays a crucial role in determining the ion …

TRP channel proteins constitute a large and diverse family of proteins that are expressed in
many tissues and cell types. This family was designated TRP because of a spontaneously …

Agonist-induced Ca 2+ entry into cells by both store-operated channels and channels
activated independently of Ca 2+-store depletion has been described in various cell types …