The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over
motivated behavior, feeding, and energy balance across species. Recent single-cell …

The high comorbidity between obesity and mental disorders, such as depression and
anxiety, often exacerbates metabolic and neurological symptoms significantly. However …

Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain
unclear. Here, we explore a hypothalamo-cerebello-amygdalar circuit that may mediate …

Fear is essential for survival, but excessive anxiety behavior is debilitating. Anxiety disorders
affecting millions of people are a global health problem, where new therapies and targets …

Cancer-related fatigue (CRF) is one of the most prevalent and detrimental complications of
cancer. Emerging evidence suggests that obesity and insulin resistance are associated with …

Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical
excitation. Abnormally high excitation produces epileptic seizures, which affect millions of …

Maladaptive coping behaviors are probably involved in post-traumatic stress disorders
(PTSD), but underlying mechanisms are incompletely understood. We now report that mice …

Objective The lateral periaqueductal gray (LPAG), which mainly contains glutamatergic
neurons, plays an important role in social responses, pain, and offensive and defensive …

Chronic cerebral hypoperfusion (CCH) is closely related to vascular cognitive impairment
and dementia (VCID) and Alzheimer's disease (AD). The neuroinflammation involving …

Abstract Objective Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the
lateral hypothalamus. It exerts powerful control over brain function and physiology by …