Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …

The most significant long-term complication of radiotherapy in the head-and-neck region is
hyposalivation and its related complaints, particularily xerostomia. This review addresses …

Background The most manifest long-term consequences of radiation therapy in the head
and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness …

A dry mouth or xerostomia is one of the most common complications during and after
radiotherapy for head and neck cancer, because irreparable damage is caused to the …

The location of the primary tumor or lymph node metastases dictates the inclusion of the oral
cavity, salivary glands, and jaws in the radiation treatment portals for patients who have …

Aquaporin-5 (AQP5) is a water-selective transporting protein expressed in epithelial cells of
serous acini in salivary gland. We generated AQP5 null mice by targeted gene disruption …

Compared with small animal models such as rodents, large animal models are superior in
many aspects for the study of human diseases and pre‐clinical therapies. Since the …

Saliva is of paramount importance for the maintenance of oral and general homeostasis.
Salivary hypofunction predispose patients to disorders such as dysgeusia, pain and burning …

Radiation therapy for head and neck cancer causes significant secondary side-effects in
normal salivary glands, resulting in diminished quality of life for these individuals. Salivary …

No conventional therapy exists for salivary hypofunction in surviving head and neck cancer
patients with Radiation Therapy Oncology Group late grade 2–3 toxicity. We conducted a …