All living organisms rely on nutrients to sustain cell metabolism and energy production,
which in turn need to be adjusted based on available resources. The evolutionarily …

Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and
energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have …

The target of rapamycin (TOR) kinase is a conserved regulatory hub that translates
environmental and nutritional information into permissive or restrictive growth decisions …

Complex multicellular organisms have evolved specific mechanisms to replenish cells in
homeostasis and during repair. Here, we discuss how emerging technologies (eg, single …

Although the eukaryotic TOR (target of rapamycin) kinase signalling pathway has emerged
as a key player for integrating nutrient-, energy-and stress-related cues with growth and …

The fission yeast Schizosaccharomyces pombe employs two main strategies to adapt to the
environment and survive when starved for nutrients. The strategies employ sporulation via …

Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in
response to intra-or extracellular signals but the underlying molecular mechanisms remain …

Target of rapamycin complex 1 (TORC1) is an important regulator of various signaling
pathways. It can control cell growth and development by integrating multiple signals from …

Cell proliferation and differentiation require signalling pathways that enforce appropriate
and timely gene expression. We find that Tor2, the catalytic subunit of the TORC1 complex in …

The fission yeast Schizosaccharomyces pombe is an excellent model organism to explore
cellular events owing to rich tools in genetics, molecular biology, cellular biology, and …