OE Brodde, MC Michel - Pharmacological reviews, 1999 - ASPET
Cardiac function is controlled by the autonomic nervous system (ie, the sympathetic and the parasympathetic nervous systems), which act via adrenoceptors and muscarinic …
M Bouvier - Nature Reviews Neuroscience, 2001 - nature.com
Examples of G-protein-coupled receptors that can be biochemically detected in homo-or heteromeric complexes are emerging at an accelerated rate. Biophysical approaches have …
ED Abel, HC Kaulbach, R Tian… - The Journal of …, 1999 - Am Soc Clin Investig
Glucose enters the heart via GLUT1 and GLUT4 glucose transporters. GLUT4-deficient mice develop striking cardiac hypertrophy and die prematurely. Whether their cardiac changes …
MA Bogoyevitch, J Gillespie-Brown… - Circulation …, 1996 - Am Heart Assoc
It has recently been recognized that cellular stresses activate certain members of the mitogen-activated protein kinase (MAPK) superfamily. One role of these “stress-activated” …
PH Sugden, A Clerk - Journal of molecular medicine, 1998 - Springer
Hypertrophy of myocytes in the heart ventricles is an important adaptation that in vivo occurs in response to a requirement for increased contractile power. It involves changes at the level …
P Kometiani, J Li, L Gnudi, BB Kahn, A Askari… - Journal of Biological …, 1998 - ASBMB
We showed before that in neonatal rat cardiac myocytes partial inhibition of Na+/K+-ATPase by nontoxic concentrations of ouabain causes hypertrophic growth and transcriptional …
H Zhong, KP Minneman - European journal of pharmacology, 1999 - Elsevier
α1-Adrenoceptors are one of three subfamilies of receptors (α1, α2, β) mediating responses to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …
GX Zhang, S Kimura, A Nishiyama… - Cardiovascular …, 2005 - academic.oup.com
Objective: Sympathetic nervous system activity in the myocardium is increased in patients with heart failure. However, the in vivo mechanisms responsible for β-adrenoceptor …
SB Wachter, EM Gilbert - Cardiology, 2012 - karger.com
Abstract β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker …